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Premium service is only $9.99 a month.You can try our streaming API via WebSockets which will automate your trading <div><?xml version="1.0"?> <ownershipDocument> <schemaVersion>X0306</schemaVersion> <documentType>4</documentType> <periodOfReport>2022-08-29</periodOfReport> <notSubjectToSection16>0</notSubjectToSection16> <issuer> <issuerCik>0001001233</issuerCik> <issuerName>SANGAMO THERAPEUTICS, INC</issuerName> <issuerTradingSymbol>SGMO</issuerTradingSymbol> </issuer> <reportingOwner> <reportingOwnerId> <rptOwnerCik>0000875045</rptOwnerCik> <rptOwnerName>BIOGEN INC.</rptOwnerName> </reportingOwnerId> <reportingOwnerAddress> <rptOwnerStreet1>225 BINNEY ST.</rptOwnerStreet1> <rptOwnerStreet2></rptOwnerStreet2> <rptOwnerCity>CAMBRIDGE</rptOwnerCity> <rptOwnerState>MA</rptOwnerState> <rptOwnerZipCode>02142</rptOwnerZipCode> <rptOwnerStateDescription></rptOwnerStateDescription> </reportingOwnerAddress> <reportingOwnerRelationship> <isDirector>0</isDirector> <isOfficer>0</isOfficer> <isTenPercentOwner>1</isTenPercentOwner> <isOther>0</isOther> </reportingOwnerRelationship> </reportingOwner> <reportingOwner> <reportingOwnerId> <rptOwnerCik>0001810387</rptOwnerCik> <rptOwnerName>Biogen MA Inc.</rptOwnerName> </reportingOwnerId> <reportingOwnerAddress> <rptOwnerStreet1>225 BINNEY ST.</rptOwnerStreet1> <rptOwnerStreet2></rptOwnerStreet2> <rptOwnerCity>CAMBRIDGE</rptOwnerCity> <rptOwnerState>MA</rptOwnerState> <rptOwnerZipCode>02142</rptOwnerZipCode> <rptOwnerStateDescription></rptOwnerStateDescription> </reportingOwnerAddress> <reportingOwnerRelationship> <isDirector>0</isDirector> <isOfficer>0</isOfficer> <isTenPercentOwner>1</isTenPercentOwner> <isOther>0</isOther> </reportingOwnerRelationship> </reportingOwner> <nonDerivativeTable> <nonDerivativeTransaction> <securityTitle> <value>Common Stock</value> </securityTitle> <transactionDate> <value>2022-08-29</value> </transactionDate> <deemedExecutionDate></deemedExecutionDate> <transactionCoding> <transactionFormType>4</transactionFormType> <transactionCode>S</transactionCode> <equitySwapInvolved>0</equitySwapInvolved> </transactionCoding> <transactionTimeliness> <value></value> </transactionTimeliness> <transactionAmounts> <transactionShares> <value>400000</value> </transactionShares> <transactionPricePerShare> <value>5.3268</value> <footnoteId id="F1"/> </transactionPricePerShare> <transactionAcquiredDisposedCode> <value>D</value> </transactionAcquiredDisposedCode> </transactionAmounts> <postTransactionAmounts> <sharesOwnedFollowingTransaction> <value>23752466</value> </sharesOwnedFollowingTransaction> </postTransactionAmounts> <ownershipNature> <directOrIndirectOwnership> <value>I</value> </directOrIndirectOwnership> <natureOfOwnership> <value>By Biogen MA Inc.</value> <footnoteId id="F2"/> </natureOfOwnership> </ownershipNature> </nonDerivativeTransaction> <nonDerivativeTransaction> <securityTitle> <value>Common Stock</value> </securityTitle> <transactionDate> <value>2022-08-30</value> </transactionDate> <deemedExecutionDate></deemedExecutionDate> <transactionCoding> <transactionFormType>4</transactionFormType> <transactionCode>S</transactionCode> <equitySwapInvolved>0</equitySwapInvolved> </transactionCoding> <transactionTimeliness> <value></value> </transactionTimeliness> <transactionAmounts> <transactionShares> <value>100000</value> </transactionShares> <transactionPricePerShare> <value>5.2652</value> <footnoteId id="F3"/> </transactionPricePerShare> <transactionAcquiredDisposedCode> <value>D</value> </transactionAcquiredDisposedCode> </transactionAmounts> <postTransactionAmounts> <sharesOwnedFollowingTransaction> <value>23652466</value> </sharesOwnedFollowingTransaction> </postTransactionAmounts> <ownershipNature> <directOrIndirectOwnership> <value>I</value> </directOrIndirectOwnership> <natureOfOwnership> <value>By Biogen MA Inc.</value> <footnoteId id="F2"/> </natureOfOwnership> </ownershipNature> </nonDerivativeTransaction> </nonDerivativeTable> <footnotes> <footnote id="F1">The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.205 to $5.475, inclusive. The reporting person undertakes to provide to Sangamo Therapeutics, Inc., any security holder of Sangamo Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.</footnote> <footnote id="F2">Shares are owned indirectly by Biogen Inc. and directly by its wholly-owned subsidiary Biogen MA Inc.</footnote> <footnote id="F3">The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $5.1235 to $5.49, inclusive. The reporting person undertakes to provide to Sangamo Therapeutics, Inc., any security holder of Sangamo Therapeutics, Inc. or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote.</footnote> </footnotes> <remarks></remarks> <ownerSignature> <signatureName>BIOGEN INC. By: /s/ Michael Dambach, Vice President and Treasurer</signatureName> <signatureDate>2022-08-31</signatureDate> </ownerSignature> <ownerSignature> <signatureName>BIOGEN MA INC. By: /s/ Michael Dambach, Vice President and Treasurer</signatureName> <signatureDate>2022-08-31</signatureDate> </ownerSignature> </ownershipDocument> <br></div> More